MECHANISM OF ACTION
ALUMINUM OR MAGNESIUM CONTAINING PRODUCTS MAY REDUCE
the bioavailability of gabapentin.(1)
DISCUSSION
In 16 subjects, Maalox reduced the bioavailability of
gabapentin by about 20%. The reduction was only 5% when gabapentin was
administered 2 hours after the Maalox dose. It is for this reason that the
manufacturer of gabapentin recommends that it be taken at least 2 hours
after the administration of aluminum or magnesium containing products.(1)
CLINICAL EFFECTS
Simultaneous administration of aluminum or magnesium
containing products and gabapentin may result in decreased absorption of
gabapentin by 20% and reduce its clinical effectiveness.(1)
SEVERITY LEVEL
3-Moderate Interaction: Assess the risk to the patient and
take action as needed.
PATIENT MANAGEMENT
If the use of both medications is unavoidable, it is
recommended that gabapentin be taken at least 2 hours following the
administration of aluminum or magnesium containing products.(1)
PREDISPOSING FACTORS
None determined.
REFERENCE