Drug-Drug Interaction
CARBAMAZEPINE/CYCLOSPORINE
MECHANISM OF ACTION
Carbamazepine may induce the metabolism of
cyclosporine.
DISCUSSION
Patients receiving concurrent carbamazepine and cyclosporine
therapy may need higher dosages of cyclosporine as a result of enzyme
induction by carbamazepine.
CLINICAL EFFECTS
Decreased levels of cyclosporine, which may result in a
decrease in the immunosuppressive effects of cyclosporine.
SEVERITY LEVEL
3-Moderate Interaction: Assess the risk to the patient and
take action as needed.
PATIENT MANAGEMENT
Monitor cyclosporine levels in patients receiving
carbamazepine and in patients in whom carbamazepine is discontinued. The
dosage of cyclosporine may need to be adjusted.
PREDISPOSING FACTORS
None determined.
REFERENCES
- Schofield OM, Camp RD, Levene GM. Cyclosporin A in psoriasis: interaction
.Schofield OM, Camp RD, Levene GM. Cyclosporin A in psoriasis: interaction
with carbamazepine. Br J Dermatol 1990 Mar;122(3):425-6.
- Lele P, Peterson P, Yang S, Jarrell B, Burke JF Jr. Cyclosporine and
.Lele P, Peterson P, Yang S, Jarrell B, Burke JF Jr. Cyclosporine and
tegretrol -- another drug interaction. Kidney Int 1985;27(1):344.
- Soto Alvarez J, Sacristan Del Castillo JA, Alsar Ortiz MJ. Effect of
.Soto Alvarez J, Sacristan Del Castillo JA, Alsar Ortiz MJ. Effect of
carbamazepine on cyclosporin blood level. Nephron 1991;58(2):235-6.
- Cooney GF, Mochon M, Kaiser B, Dunn SP, Goldsmith B. Effects of
.Cooney GF, Mochon M, Kaiser B, Dunn SP, Goldsmith B. Effects of
carbamazepine on cyclosporine metabolism in pediatric renal transplant
recipients. Pharmacotherapy 1995 May-Jun;15(3):353-6.